Effects of NS2B-NS3 protease and furin inhibition on West Nile and Dengue virus replication

• Main Authors: Jenny Kouretova (Author), M. Zouhir Hammamy (Author), Anton Epp (Author), Kornelia Hardes (Author), Stephanie Kallis (Author), Linlin Zhang (Author), Rolf Hilgenfeld (Author), Ralf Bartenschlager (Author), Torsten Steinmetzer (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

West Nile virus (WNV) and Dengue virus (DENV) replication depends on the viral NS2B-NS3 protease and the host enzyme furin, which emerged as potential drug targets. Modification of our previously described WNV protease inhibitors by basic phenylalanine analogs provided compounds with reduced potency...