Effects of NS2B-NS3 protease and furin inhibition on West Nile and Dengue virus replication

• Päätekijät: Jenny Kouretova (Tekijä), M. Zouhir Hammamy (Tekijä), Anton Epp (Tekijä), Kornelia Hardes (Tekijä), Stephanie Kallis (Tekijä), Linlin Zhang (Tekijä), Rolf Hilgenfeld (Tekijä), Ralf Bartenschlager (Tekijä), Torsten Steinmetzer (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

West Nile virus (WNV) and Dengue virus (DENV) replication depends on the viral NS2B-NS3 protease and the host enzyme furin, which emerged as potential drug targets. Modification of our previously described WNV protease inhibitors by basic phenylalanine analogs provided compounds with reduced potency...