Effects of NS2B-NS3 protease and furin inhibition on West Nile and Dengue virus replication

• Asıl Yazarlar: Jenny Kouretova (Yazar), M. Zouhir Hammamy (Yazar), Anton Epp (Yazar), Kornelia Hardes (Yazar), Stephanie Kallis (Yazar), Linlin Zhang (Yazar), Rolf Hilgenfeld (Yazar), Ralf Bartenschlager (Yazar), Torsten Steinmetzer (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

West Nile virus (WNV) and Dengue virus (DENV) replication depends on the viral NS2B-NS3 protease and the host enzyme furin, which emerged as potential drug targets. Modification of our previously described WNV protease inhibitors by basic phenylalanine analogs provided compounds with reduced potency...