Effects of NS2B-NS3 protease and furin inhibition on West Nile and Dengue virus replication

• 主要な著者: Jenny Kouretova (著者), M. Zouhir Hammamy (著者), Anton Epp (著者), Kornelia Hardes (著者), Stephanie Kallis (著者), Linlin Zhang (著者), Rolf Hilgenfeld (著者), Ralf Bartenschlager (著者), Torsten Steinmetzer (著者)
• フォーマット: 図書
• 出版事項: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

West Nile virus (WNV) and Dengue virus (DENV) replication depends on the viral NS2B-NS3 protease and the host enzyme furin, which emerged as potential drug targets. Modification of our previously described WNV protease inhibitors by basic phenylalanine analogs provided compounds with reduced potency...