Fragment-Based Lead Discovery Strategies in Antimicrobial Drug Discovery

• मुख्य लेखकों: Monika I. Konaklieva (लेखक), Balbina J. Plotkin (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2023-02-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Fragment-based lead discovery (FBLD) is a powerful application for developing ligands as modulators of disease targets. This approach strategy involves identification of interactions between low-molecular weight compounds (100-300 Da) and their putative targets, often with low affinity (K<sub>...