Bi-Functional Alginate Oligosaccharide-Polymyxin Conjugates for Improved Treatment of Multidrug-Resistant Gram-Negative Bacterial Infections

• Main Authors: Joana Stokniene (Author), Lydia C. Powell (Author), Olav A. Aarstad (Author), Finn L. Aachmann (Author), Philip D. Rye (Author), Katja E. Hill (Author), David W. Thomas (Author), Elaine L. Ferguson (Author)
• Format: Book
• Published: MDPI AG, 2020-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The recent emergence of resistance to colistin, an antibiotic of last resort with dose-limiting toxicity, has highlighted the need for alternative approaches to combat infection. This study aimed to generate and characterise alginate oligosaccharide ("OligoG")-polymyxin (polymyxin B and E...