Plasma concentration and efficacy of tolvaptan in cirrhotic patients with refractory ascites

• প্রধান লেখক: Eri Sagawa (লেখক), Hironao Okubo (লেখক), Hitoshi Ando (লেখক), Yushi Sorin (লেখক), Ryo Kanazawa (লেখক), Eisuke Nakadera (লেখক), Hiroo Fukada (লেখক), Shigehiro Kokubu (লেখক), Akihisa Miyazaki (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Elsevier, 2019-04-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

To investigate the relationship between the exposure and efficacy of tolvaptan, we measured pharmacokinetics of total drug at 7 days after repeated doses of 3.75 mg/day tolvaptan in 16 patients with hepatic edema. Nine patients (56.3%) were responders, which were defined as those with body weight re...