Plasma concentration and efficacy of tolvaptan in cirrhotic patients with refractory ascites

• Main Authors: Eri Sagawa (Author), Hironao Okubo (Author), Hitoshi Ando (Author), Yushi Sorin (Author), Ryo Kanazawa (Author), Eisuke Nakadera (Author), Hiroo Fukada (Author), Shigehiro Kokubu (Author), Akihisa Miyazaki (Author)
• Format: Book
• Published: Elsevier, 2019-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

To investigate the relationship between the exposure and efficacy of tolvaptan, we measured pharmacokinetics of total drug at 7 days after repeated doses of 3.75 mg/day tolvaptan in 16 patients with hepatic edema. Nine patients (56.3%) were responders, which were defined as those with body weight re...