Improved Metal-Free Approach for the Synthesis of Protected Thiol Containing Thymidine Nucleoside Phosphoramidite and Its Application for the Synthesis of Ligatable Oligonucleotide Conjugates

• Main Authors: Zoltán Kupihár (Author), Györgyi Ferenc (Author), Vencel L. Petrovicz (Author), Viktória R. Fáy (Author), Lajos Kovács (Author), Tamás A. Martinek (Author), Zsófia Hegedüs (Author)
• Format: Book
• Published: MDPI AG, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oligonucleotide conjugates are versatile scaffolds that can be applied in DNA-based screening platforms and ligand display or as therapeutics. Several different chemical approaches are available for functionalizing oligonucleotides, which are often carried out on the 5' or 3' end. Modifyin...