Improved Metal-Free Approach for the Synthesis of Protected Thiol Containing Thymidine Nucleoside Phosphoramidite and Its Application for the Synthesis of Ligatable Oligonucleotide Conjugates

• Auteurs principaux: Zoltán Kupihár (Auteur), Györgyi Ferenc (Auteur), Vencel L. Petrovicz (Auteur), Viktória R. Fáy (Auteur), Lajos Kovács (Auteur), Tamás A. Martinek (Auteur), Zsófia Hegedüs (Auteur)
• Format: Livre
• Publié: MDPI AG, 2023-01-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Oligonucleotide conjugates are versatile scaffolds that can be applied in DNA-based screening platforms and ligand display or as therapeutics. Several different chemical approaches are available for functionalizing oligonucleotides, which are often carried out on the 5' or 3' end. Modifyin...