Development of a Biodegradable PLGA Carrier to Provide Wnt Agonists and Antibiotics to Meet the Requirements for Patients with Bone Infections

• Main Authors: Song-Shu Lin (Author), Shih-Jung Liu (Author), Err-Cheng Chan (Author), Kowit-Yu Chong (Author), Yi-Sheng Chan (Author), Tsung-Ting Tsai (Author), Chi-Chien Niu (Author), Li-Jen Yuan (Author), Chuen-Yung Yang (Author), Hui-Yi Hsiao (Author), Yi-Jen Hsueh (Author), Chung-An Chen (Author), Steve W. N. Ueng (Author)
• Format: Book
• Published: MDPI AG, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Antibiotic beads can be used to treat surgical infections. In this study, polylactide-polyglycolide (PLGA) was mixed with vancomycin, the osteogenic enhancer lithium chloride (LiCl), and hot compression to form PLGA-vancomycin-LiCl delivery beads to treat bone infection. An elution method was used t...