Brain Transcriptome Analysis Links Deficiencies of Stress-Responsive Proteins to the Pathomechanism of Kii ALS/PDC

• Main Authors: Satoru Morimoto (Author), Mitsuru Ishikawa (Author), Hirotaka Watanabe (Author), Miho Isoda (Author), Masaki Takao (Author), Shiho Nakamura (Author), Fumiko Ozawa (Author), Yoshifumi Hirokawa (Author), Shigeki Kuzuhara (Author), Hideyuki Okano (Author), Yasumasa Kokubo (Author)
• Format: Book
• Published: MDPI AG, 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Amyotrophic lateral sclerosis and Parkinsonism-dementia complex (ALS/PDC) is a unique endemic neurodegenerative disease, with high-incidence foci in Kii Peninsula, Japan. To gather new insights into the pathological mechanisms underlying Kii ALS/PDC, we performed transcriptome analyses of patient br...