Inhibitory Effect of Trimidox on Lipopolysaccharide-Induced Nitric Oxide Production in RAW 264.7 Macrophages

• Main Authors: Syu-ichi Kanno (Author), Mai Kakuta (Author), Yasue Kitajima (Author), Yuu Osanai (Author), Kaori Kurauchi (Author), Takaharu Ohtake (Author), Mayuko Ujibe (Author), Kouji Uwai (Author), Mituhiro Takeshita (Author), Masaaki Ishikawa (Author)
• Format: Book
• Published: Elsevier, 2007-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We examined the effect of trimidox (3,4,5-trihydroxybenzamidoxime) on the production of nitric oxide (NO) by lipopolysaccharide (LPS) in mouse RAW 264.7 macrophages. Trimidox (50 - 300 µM) concentration-dependently inhibited NO production by LPS (0.01, 0.1, or 1 µg/ml) after incubation for 24 h. LPS...