Chemical induction of gut β-like-cells by combined FoxO1/Notch inhibition as a glucose-lowering treatment for diabetes

• Main Authors: Takumi Kitamoto (Author), Yun-Kyoung Lee (Author), Nishat Sultana (Author), Hitoshi Watanabe (Author), Wendy M. McKimpson (Author), Wen Du (Author), Jason Fan (Author), Bryan Diaz (Author), Hua V. Lin (Author), Rudolph L. Leibel (Author), Sandro Belvedere (Author), Domenico Accili (Author)
• Format: Book
• Published: Elsevier, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Lifelong insulin replacement remains the mainstay of type 1 diabetes treatment. Genetic FoxO1 ablation promotes enteroendocrine cell (EECs) conversion into glucose-responsive β-like cells. Here, we tested whether chemical FoxO1 inhibitors can generate β-like gut cells. Methods: We used Ng...