Global changes in nitration levels and DNA binding profile of Trypanosoma cruzi histones induced by incubation with host extracellular matrix.

• Main Authors: Rubens Daniel Miserani Magalhães (Author), Eliciane Cevolani Mattos (Author), Andrei Rozanski (Author), Pedro Alexandre Favoretto Galante (Author), Giuseppe Palmisano (Author), Angela Kaysel Cruz (Author), Walter Colli (Author), Anamaria Aranha Camargo (Author), Maria Júlia Manso Alves (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Adhesion of T. cruzi trypomastigotes to components of the extracellular matrix (ECM) is an important step in mammalian host cell invasion. We have recently described a significant increase in the tyrosine nitration levels of histones H2A and H4 when trypomastigotes are incubated with components of t...