Combining mathematical modeling, in vitro data and clinical target expression to support bispecific antibody binding affinity selection: a case example with FAP-4-1BBL

• Egile Nagusiak: Javier Sanchez (Egilea), Christina Claus (Egilea), Christine McIntyre (Egilea), Tamara Tanos (Egilea), Axel Boehnke (Egilea), Lena E. Friberg (Egilea), Siv Jönsson (Egilea), Nicolas Frances (Egilea)
• Formatua: Liburua
• Argitaratua: Frontiers Media S.A., 2024-10-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

The majority of bispecific costimulatory antibodies in cancer immunotherapy are capable of exerting tumor-specific T-cell activation by simultaneously engaging both tumor-associated targets and costimulatory receptors expressed by T cells. The amount of trimeric complex formed when the bispecific an...