Combining mathematical modeling, in vitro data and clinical target expression to support bispecific antibody binding affinity selection: a case example with FAP-4-1BBL

• Main Authors: Javier Sanchez (Author), Christina Claus (Author), Christine McIntyre (Author), Tamara Tanos (Author), Axel Boehnke (Author), Lena E. Friberg (Author), Siv Jönsson (Author), Nicolas Frances (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The majority of bispecific costimulatory antibodies in cancer immunotherapy are capable of exerting tumor-specific T-cell activation by simultaneously engaging both tumor-associated targets and costimulatory receptors expressed by T cells. The amount of trimeric complex formed when the bispecific an...