Multikinase Abl/DDR/Src Inhibition Produces Optimal Effects for Tyrosine Kinase Inhibition in Neurodegeneration

• Main Authors: Alan J. Fowler (Author), Michaeline Hebron (Author), Alexander A. Missner (Author), Ruchong Wang (Author), Xiaokong Gao (Author), Bahjat T. Kurd-Misto (Author), Xiaoguang Liu (Author), Charbel E.-H. Moussa (Author)
• Format: Book
• Published: Adis, Springer Healthcare, 2019-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background and objectives Inhibition of Abelson (Abl) tyrosine kinase as a therapeutic target has been gaining attention in neurodegeneration. Post-mortem Alzheimer's and Parkinson's disease brains show that the levels of several other tyrosine kinases, including Discoidin Domain...