A gut-brain axis regulating glucose metabolism mediated by bile acids and competitive fibroblast growth factor actions at the hypothalamus

• Main Authors: Shunmei Liu (Author), Genevieve Marcelin (Author), Clemence Blouet (Author), Jae Hoon Jeong (Author), Young-Hwan Jo (Author), Gary J. Schwartz (Author), Streamson Chua, Jr (Author)
• Format: Book
• Published: Elsevier, 2018-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Bile acids have been implicated as important regulators of glucose metabolism via activation of FXR and GPBAR1. We have previously shown that FGF19 can modulate glucose handling by suppressing the activity of hypothalamic AGRP/NPY neurons. As bile acids stimulate the release of FGF19/FGF1...