Novel Selective IDO1 Inhibitors with Isoxazolo[5,4-<i>d</i>]pyrimidin-4(5<i>H</i>)-one Scaffold

Novel Selective IDO1 Inhibitors with Isoxazolo[5,4-<i>d</i>]pyrimidin-4(5<i>H</i>)-one Scaffold

Indoleamine 2,3-dioxygenase 1 (IDO1) is a promising target in immunomodulation of several pathological conditions, especially cancers. Here we present the synthesis of a series of IDO1 inhibitors with the novel isoxazolo[5,4-<i>d</i>]pyrimidin-4(5<i>H</i>)-one scaffold. A foc...

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Main Authors: Ana Dolšak (Author), Tomaž Bratkovič (Author), Larisa Mlinarič (Author), Eva Ogorevc (Author), Urban Švajger (Author), Stanislav Gobec (Author), Matej Sova (Author)
Format: Book
Published: MDPI AG, 2021-03-01T00:00:00Z.
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