Vascular defects of DYRK1A knockouts are ameliorated by modulating calcium signaling in zebrafish

• Main Authors: Hyun-Ju Cho (Author), Jae-Geun Lee (Author), Jong-Hwan Kim (Author), Seon-Young Kim (Author), Yang Hoon Huh (Author), Hyo-Jeong Kim (Author), Kyu-Sun Lee (Author), Kweon Yu (Author), Jeong-Soo Lee (Author)
• Format: Book
• Published: The Company of Biologists, 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

DYRK1A is a major causative gene in Down syndrome (DS). Reduced incidence of solid tumors such as neuroblastoma in DS patients and increased vascular anomalies in DS fetuses suggest a potential role of DYRK1A in angiogenic processes, but in vivo evidence is still scarce. Here, we used zebrafish dyrk...