Vascular defects of DYRK1A knockouts are ameliorated by modulating calcium signaling in zebrafish

• প্রধান লেখক: Hyun-Ju Cho (লেখক), Jae-Geun Lee (লেখক), Jong-Hwan Kim (লেখক), Seon-Young Kim (লেখক), Yang Hoon Huh (লেখক), Hyo-Jeong Kim (লেখক), Kyu-Sun Lee (লেখক), Kweon Yu (লেখক), Jeong-Soo Lee (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: The Company of Biologists, 2019-05-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

DYRK1A is a major causative gene in Down syndrome (DS). Reduced incidence of solid tumors such as neuroblastoma in DS patients and increased vascular anomalies in DS fetuses suggest a potential role of DYRK1A in angiogenic processes, but in vivo evidence is still scarce. Here, we used zebrafish dyrk...