Autocrine negative feedback regulation of lipolysis through sensing of NEFAs by FFAR4/GPR120 in WAT

• Main Authors: Anna Sofie Husted (Author), Jeppe H. Ekberg (Author), Emma Tripp (Author), Tinne A.D. Nissen (Author), Stijn Meijnikman (Author), Shannon L. O'Brien (Author), Trond Ulven (Author), Yair Acherman (Author), Sjoerd C. Bruin (Author), Max Nieuwdorp (Author), Zach Gerhart-Hines (Author), Davide Calebiro (Author), Lars O. Dragsted (Author), Thue W. Schwartz (Author)
• Format: Book
• Published: Elsevier, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Long-chain fatty acids (LCFAs) released from adipocytes inhibit lipolysis through an unclear mechanism. We hypothesized that the LCFA receptor, FFAR4 (GPR120), which is highly expressed in adipocytes, may be involved in this feedback regulation. Methods and results: Liquid chromatography...