Insulin and IGF-1 elicit robust transcriptional regulation to modulate autophagy in astrocytes

• Main Authors: Shawn J. Geffken (Author), Sohyun Moon (Author), Catherine O. Smith (Author), Sharon Tang (Author), Hiu Ham Lee (Author), Kevin Lewis (Author), Chun Wa Wong (Author), Yuan Huang (Author), Qian Huang (Author), Ying-Tao Zhao (Author), Weikang Cai (Author)
• Format: Book
• Published: Elsevier, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Insulin is a principal metabolic hormone. It regulates a plethora of metabolic pathways in peripheral tissues. The highly homologous insulin-like growth factor 1 (IGF-1), on the other hand, is important for development and growth. Recent studies have shown that insulin and IGF-1 signaling...