Synthesis, antimycobacterial evaluation, and molecular docking study of 1,2,4-triazole derivatives

• Κύριοι συγγραφείς: Meng-Yu Xia (Συγγραφέας), Yu-Xiang Cai (Συγγραφέας), Jun-Xian Chen (Συγγραφέας), Xin Zhao (Συγγραφέας), Hong-Mei Dong (Συγγραφέας), Zai-Chang Yang (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Fifteen 1,2,4-triazole derivatives were synthesised in this study and their MIC values against Mycobacterium tuberculosis (Mtb) ranged from 2 to 32 μg/mL. Furthermore, their antimycobacterial activity was positively correlated with the KatG enzyme docking score. Among the 15 compounds, compound 4 sh...