ELAC2/RNaseZ-linked cardiac hypertrophy in Drosophila melanogaster

• Main Authors: Ekaterina Migunova (Author), Joanna Theophilopoulos (Author), Marisa Mercadante (Author), Jing Men (Author), Chao Zhou (Author), Edward B. Dubrovsky (Author)
• Format: Book
• Published: The Company of Biologists, 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A severe form of infantile cardiomyopathy (CM) has been linked to mutations in ELAC2, a highly conserved human gene. It encodes Zinc phosphodiesterase ELAC protein 2 (ELAC2), which plays an essential role in the production of mature tRNAs. To establish a causal connection between ELAC2 variants and...