Tuning Design Parameters of ICAM-1-Targeted 3DNA Nanocarriers to Optimize Pulmonary Targeting Depending on Drug Type

• Principais autores: Nikša Roki (Autor), Melani Solomon (Autor), Jessica Bowers (Autor), Lori Getts (Autor), Robert C. Getts (Autor), Silvia Muro (Autor)
• Formato: Livro
• Publicado em: MDPI AG, 2022-07-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

3DNA holds promise as a carrier for drugs that can be intercalated into its core or linked to surface arms. Coupling 3DNA to an antibody targeting intercellular adhesion molecule 1 (ICAM-1) results in high lung-specific biodistributions in vivo. While the role of individual parameters on ICAM-1 targ...