Multi-stage structure-based virtual screening approach towards identification of potential SARS-CoV-2 NSP13 helicase inhibitors

• Main Authors: Mahmoud A. El Hassab (Author), Wagdy M. Eldehna (Author), Sara T. Al-Rashood (Author), Amal Alharbi (Author), Razan O. Eskandrani (Author), Hamad M. Alkahtani (Author), Eslam B. Elkaeed (Author), Sahar M. Abou-Seri (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

On account of its crucial role in the virus life cycle, SARS-COV-2 NSP13 helicase enzyme was exploited as a promising target to identify a novel potential inhibitor using multi-stage structure-based drug discovery approaches. Firstly, a 3D pharmacophore was generated based on the collected data from...