Paeoniflorin alleviates 17α-ethinylestradiol-induced cholestasis via the farnesoid X receptor-mediated bile acid homeostasis signaling pathway in rats

• Main Authors: Rulin Wang (Author), Tengteng Yuan (Author), Jing Sun (Author), Menghuan Yang (Author), Yunna Chen (Author), Lei Wang (Author), Yanyan Wang (Author), Weidong Chen (Author), Daiyin Peng (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cholestasis, characterized by disturbance of bile formation, is a common pathological condition that can induce several serious liver diseases. As a kind of trigger, estrogen-induced cholestasis belongs to drug-induced cholestasis. Paeoniflorin is the most abundant bioactive constituent in Paeonia l...