Phenotypic, chemical and functional characterization of cyclic nucleotide phosphodiesterase 4 (PDE4) as a potential anthelmintic drug target.

• Main Authors: Thavy Long (Author), Liliana Rojo-Arreola (Author), Da Shi (Author), Nelly El-Sakkary (Author), Kurt Jarnagin (Author), Fernando Rock (Author), Maliwan Meewan (Author), Alberto A Rascón (Author), Lin Lin (Author), Katherine A Cunningham (Author), George A Lemieux (Author), Larissa Podust (Author), Ruben Abagyan (Author), Kaveh Ashrafi (Author), James H McKerrow (Author), Conor R Caffrey (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Reliance on just one drug to treat the prevalent tropical disease, schistosomiasis, spurs the search for new drugs and drug targets. Inhibitors of human cyclic nucleotide phosphodiesterases (huPDEs), including PDE4, are under development as novel drugs to treat a range of chronic indications includi...