Model-based approach to the design of pharmaceutical roller-compaction processes

• Main Authors: Peter Toson (Author), Diogo G. Lopes (Author), Raphael Paus (Author), Ashish Kumar (Author), Jeroen Geens (Author), Sandy Stibale (Author), Julian Quodbach (Author), Peter Kleinebudde (Author), Wen-Kai Hsiao (Author), Johannes Khinast (Author)
• Format: Book
• Published: Elsevier, 2019-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This work presents a new model based approach to process design and scale-up within the same equipment of a roller compaction process. The prediction of the operating space is not performed fully in-silico, but uses low-throughput experiments as input. This low-throughput data is utilized in an iter...