Urotensin II Induces Mice Skeletal Muscle Atrophy Associated with Enhanced Autophagy and Inhibited Irisin Precursor (Fibronectin Type III Domain Containing 5) Expression in Chronic Renal Failure

• Main Authors: Ya-Jing Pan (Author), Si-Jia Zhou (Author), Jin Feng (Author), Qiong Bai (Author), La-Ta A (Author), Ai-Hua Zhang (Author)
• Format: Book
• Published: Karger Publishers, 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background/Aims: Skeletal muscle atrophy is one of the main manifestations of protein energy wasting. We hypothesized that urotensin II (UII) can lead to skeletal muscle atrophy through upregulating autophagy and affecting Irisin precursor fibronectin type III domain containing 5 (FNDC5) expressions...