Molecular Insight into <em>Mycobacterium tuberculosis</em> Resistance to Nitrofuranyl Amides Gained through Metagenomics-like Analysis of Spontaneous Mutants

• मुख्य लेखकों: Igor Mokrousov (लेखक), Ivaylo Slavchev (लेखक), Natalia Solovieva (लेखक), Marine Dogonadze (लेखक), Anna Vyazovaya (लेखक), Violeta Valcheva (लेखक), Aleksey Masharsky (लेखक), Olesya Belopolskaya (लेखक), Simeon Dimitrov (लेखक), Viacheslav Zhuravlev (लेखक), Isabel Portugal (लेखक), João Perdigão (लेखक), Georgi M. Dobrikov (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2022-09-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

We performed synthesis of new nitrofuranyl amides and investigated their anti-TB activity and primary genetic response of mycobacteria through whole-genome sequencing (WGS) of spontaneous resistant mutants. The in vitro activity was assessed on reference strain <i>Mycobacterium tuberculosis<...