In vivo pharmacokinetic study of remdesivir dry powder for inhalation in hamsters

• Main Authors: Sawittree Sahakijpijarn (Author), Chaeho Moon (Author), Zachary N. Warnken (Author), Esther Y. Maier (Author), Jennie E. DeVore (Author), Dale J. Christensen (Author), John J. Koleng (Author), Robert O. Williams, III (Author)
• Format: Book
• Published: Elsevier, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Remdesivir dry powder for inhalation was previously developed using thin film freezing (TFF). A single-dose 24-h pharmacokinetic study in hamsters demonstrated that pulmonary delivery of TFF remdesivir can achieve plasma remdesivir and GS-441524 levels higher than the reported EC50s of both remdesiv...