Idebenone alleviates doxorubicin-induced cardiotoxicity by stabilizing FSP1 to inhibit ferroptosis

• Main Authors: Hongliang Qiu (Author), Sihui Huang (Author), Yuting Liu (Author), Libo Liu (Author), Fengming Guo (Author), Yingying Guo (Author), Dan Li (Author), Xianfeng Cen (Author), Yajie Chen (Author), Meng Zhang (Author), Yan Che (Author), Man Xu (Author), Qizhu Tang (Author)
• Format: Book
• Published: Elsevier, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Doxorubicin (DOX)-mediated cardiotoxicity can exacerbate mortality in oncology patients, but related pharmacotherapeutic measures are relatively limited. Ferroptosis was recently identified as a major mechanism of DOX-induced cardiotoxicity. Idebenone, a novel ferroptosis inhibitor, is a well-descri...