Reversal of angiotensin ll-induced β-cell dedifferentiation via inhibition of NF-κb signaling

• Main Authors: Hong Chen (Author), Wenjun Zhou (Author), Yuting Ruan (Author), Lei Yang (Author), Ningning Xu (Author), Rongping Chen (Author), Rui Yang (Author), Jia Sun (Author), Zhen Zhang (Author)
• Format: Book
• Published: BMC, 2018-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Type 2 diabetes mellitus (T2DM) is characterized by pancreatic β-cell failure, which arises from metabolic stress and results in β cell dedifferentiation, leading to β-cell death. Pathological activation of the renin-angiotensin system (RAS) contributes to increase cell stress, w...