Pharmacokinetic Alteration of Paclitaxel by Ferulic Acid Derivative

• Main Authors: Jaeok Lee (Author), Song Wha Chae (Author), LianJi Ma (Author), So Yeon Lim (Author), Sarah Alnajjar (Author), Hea-Young Park Choo (Author), Hwa Jeong Lee (Author), Sandy Jeong Rhie (Author)
• Format: Book
• Published: MDPI AG, 2019-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

P-glycoprotein (P-gp) is known to be involved in multidrug resistance (MDR) and modulation of pharmacokinetic (PK) profiles of substrate drugs. Here, we studied the effects of synthesized ferulic acid (FA) derivatives on P-gp function in vitro and examined PK alteration of paclitaxel (PTX), a well-k...