Individual features of the pharmacokinetics of fludarabin phosphate in the treatment of patients with chronic lymphocytic leukemia

• Main Authors: G. G. Rodionov (Author), I. I. Shantyr (Author), V. B. Vasilyuk (Author), E. A. Kolobova (Author), E. V. Svetkina (Author), M. V. Faraponova (Author), A. B. Verveda (Author), G. I. Syraeva (Author), K. A. Zakharov (Author)
• Format: Book
• Published: Izdatelstvo OKI, 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Fludarabine is a purine antimetabolite with a pronounced immunosuppressive effect. The inhibitory effect of fludarabine depends on its concentration in blood plasma. In addition, the phenotypic characteristics of patients affect the pharmacokinetic and pharmacodynamic profile of the drug, which nece...