Tracking Radiolabeled Endothelial Microvesicles Predicts Their Therapeutic Efficacy: A Proof-of-Concept Study in Peripheral Ischemia Mouse Model Using SPECT/CT Imaging

• Main Authors: Romain Giraud (Author), Anaïs Moyon (Author), Stéphanie Simoncini (Author), Anne-Claire Duchez (Author), Vincent Nail (Author), Corinne Chareyre (Author), Ahlem Bouhlel (Author), Laure Balasse (Author), Samantha Fernandez (Author), Loris Vallier (Author), Guillaume Hache (Author), Florence Sabatier (Author), Françoise Dignat-George (Author), Romaric Lacroix (Author), Benjamin Guillet (Author), Philippe Garrigue (Author)
• Format: Book
• Published: MDPI AG, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Microvesicles, so-called endothelial large extracellular vesicles (LEVs), are of great interest as biological markers and cell-free biotherapies in cardiovascular and oncologic diseases. However, their therapeutic perspectives remain limited due to the lack of reliable data regarding their systemic...