SBF-1 inhibits contact hypersensitivity in mice through down-regulation of T-cell-mediated responses

• Main Authors: Wei Chen (Author), Xianying Fang (Author), Yuan Gao (Author), Ke Shi (Author), Lijun Sun (Author), Biao Yu (Author), Qiong Luo (Author), Qiang Xu (Author)
• Format: Book
• Published: BMC, 2019-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background T lymphocytes play an important role in contact hypersensitivity. This study aims to explore the immunosuppressive activity of SBF-1, an analog of saponin OSW-1, against T lymphocytes in vitro and in vivo. Methods Proliferation of T lymphocytes from lymph nodes of mice was determ...