Crosstalk between CYP2E1 and PPARα substrates and agonists modulate adipose browning and obesity

• Main Authors: Youbo Zhang (Author), Tingting Yan (Author), Tianxia Wang (Author), Xiaoyan Liu (Author), Keisuke Hamada (Author), Dongxue Sun (Author), Yizheng Sun (Author), Yanfang Yang (Author), Jing Wang (Author), Shogo Takahashi (Author), Qiong Wang (Author), Kristopher W. Krausz (Author), Changtao Jiang (Author), Cen Xie (Author), Xiuwei Yang (Author), Frank J. Gonzalez (Author)
• Format: Book
• Published: Elsevier, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Although the functions of metabolic enzymes and nuclear receptors in controlling physiological homeostasis have been established, their crosstalk in modulating metabolic disease has not been explored. Genetic ablation of the xenobiotic-metabolizing cytochrome P450 enzyme CYP2E1 in mice markedly indu...