Crosstalk between CYP2E1 and PPARα substrates and agonists modulate adipose browning and obesity

• প্রধান লেখক: Youbo Zhang (লেখক), Tingting Yan (লেখক), Tianxia Wang (লেখক), Xiaoyan Liu (লেখক), Keisuke Hamada (লেখক), Dongxue Sun (লেখক), Yizheng Sun (লেখক), Yanfang Yang (লেখক), Jing Wang (লেখক), Shogo Takahashi (লেখক), Qiong Wang (লেখক), Kristopher W. Krausz (লেখক), Changtao Jiang (লেখক), Cen Xie (লেখক), Xiuwei Yang (লেখক), Frank J. Gonzalez (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Elsevier, 2022-05-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Although the functions of metabolic enzymes and nuclear receptors in controlling physiological homeostasis have been established, their crosstalk in modulating metabolic disease has not been explored. Genetic ablation of the xenobiotic-metabolizing cytochrome P450 enzyme CYP2E1 in mice markedly indu...