Influence of Single Nucleotide Polymorphisms on Rifampin Pharmacokinetics in Tuberculosis Patients

• Main Authors: Levin Thomas (Author), Sonal Sekhar Miraj (Author), Mallayasamy Surulivelrajan (Author), Muralidhar Varma (Author), Chidananda S. V. Sanju (Author), Mahadev Rao (Author)
• Format: Book
• Published: MDPI AG, 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Rifampin (RF) is metabolized in the liver into an active metabolite 25-desacetylrifampin and excreted almost equally via biliary and renal routes. Various influx and efflux transporters influence RF disposition during hepatic uptake and biliary excretion. Evidence has also shown that Vitamin D defic...