Influence of Single Nucleotide Polymorphisms on Rifampin Pharmacokinetics in Tuberculosis Patients

• Главные авторы: Levin Thomas (Автор), Sonal Sekhar Miraj (Автор), Mallayasamy Surulivelrajan (Автор), Muralidhar Varma (Автор), Chidananda S. V. Sanju (Автор), Mahadev Rao (Автор)
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• Опубликовано: MDPI AG, 2020-06-01T00:00:00Z.
• Предметы: article
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Rifampin (RF) is metabolized in the liver into an active metabolite 25-desacetylrifampin and excreted almost equally via biliary and renal routes. Various influx and efflux transporters influence RF disposition during hepatic uptake and biliary excretion. Evidence has also shown that Vitamin D defic...