Influenza a virus triggers acute exacerbation of chronic obstructive pulmonary disease by increasing proinflammatory cytokines secretion via NLRP3 inflammasome activation

• Main Authors: Shuang Ji (Author), Meng-Yuan Dai (Author), Yun Huang (Author), Xiang-Chun Ren (Author), Meng-Long Jiang (Author), Jin-Ping Qiao (Author), Wen-Ying Zhang (Author), Yuan-Hong Xu (Author), Ji-Long Shen (Author), Ren-Quan Zhang (Author), Guang-He Fei (Author)
• Format: Book
• Published: BMC, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Influenza A virus (IAV) triggers acute exacerbation of chronic obstructive pulmonary disease (AECOPD), but the molecular mechanisms remain unclear. In this study, we investigated the role of IAV induced NLRP3 inflammasome activation to increase airway inflammation response in the...