Rapid depletion of "catch-and-release" anti-ASGR1 antibody in vivo

• Main Authors: Siva Charan Devanaboyina (Author), Peng Li (Author), Edward L. LaGory (Author), Carrie Poon-Andersen (Author), Kevin D. Cook (Author), Marcus Soto (Author), Zhe Wang (Author), Khue Dang (Author), Craig Uyeda (Author), Ryan B. Case (Author), Veena A. Thomas (Author), Ronya Primack (Author), Manuel Ponce (Author), Mei Di (Author), Brian Ouyang (Author), Joelle Kaner (Author), Sheung Kwan Lam (Author), Mina Mostafavi (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Targeting antigens with antibodies exhibiting pH/Ca2+-dependent binding against an antigen is an attractive strategy to mitigate target-mediated disposition and antigen buffering. Studies have reported improved serum exposure of antibodies exhibiting pH/Ca2+-binding against membrane-bound receptors....