NKG2D promotes CD8 T cell-mediated cytotoxicity and is associated with treatment failure in human cutaneous leishmaniasis.

• Main Authors: Laís A Sacramento (Author), Camila Farias Amorim (Author), Taís M Campos (Author), Maíra Saldanha (Author), Sérgio Arruda (Author), Lucas P Carvalho (Author), Daniel P Beiting (Author), Edgar M Carvalho (Author), Fernanda O Novais (Author), Phillip Scott (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cutaneous leishmaniasis exhibits a spectrum of clinical presentations dependent upon the parasites' persistence and host immunopathologic responses. Although cytolytic CD8 T cells cannot control the parasites, they significantly contribute to pathologic responses. In a murine model of cutaneous...