NKG2D promotes CD8 T cell-mediated cytotoxicity and is associated with treatment failure in human cutaneous leishmaniasis.

• Egile Nagusiak: Laís A Sacramento (Egilea), Camila Farias Amorim (Egilea), Taís M Campos (Egilea), Maíra Saldanha (Egilea), Sérgio Arruda (Egilea), Lucas P Carvalho (Egilea), Daniel P Beiting (Egilea), Edgar M Carvalho (Egilea), Fernanda O Novais (Egilea), Phillip Scott (Egilea)
• Formatua: Liburua
• Argitaratua: Public Library of Science (PLoS), 2023-08-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Cutaneous leishmaniasis exhibits a spectrum of clinical presentations dependent upon the parasites' persistence and host immunopathologic responses. Although cytolytic CD8 T cells cannot control the parasites, they significantly contribute to pathologic responses. In a murine model of cutaneous...