Ascorbate sensitizes human osteosarcoma cells to the cytostatic effects of cisplatin

• Main Authors: Naohiro Oka (Author), Akiyoshi Komuro (Author), Hisayuki Amano (Author), Suman Dash (Author), Masahiko Honda (Author), Kazushige Ota (Author), Shunji Nishimura (Author), Takeshi Ueda (Author), Masao Akagi (Author), Hitoshi Okada (Author)
• Format: Book
• Published: Wiley, 2020-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Osteosarcoma (OS) is the most common malignant bone tumor and a leading cause of cancer‐related deaths in children and adolescents. Current standard treatments for OS are a combination of preoperative chemotherapy, surgical resection, and adjuvant chemotherapy. Cisplatin is used as the stan...