Engineering human skin model innervated with itch sensory neuron‐like cells differentiated from induced pluripotent stem cells

• Main Authors: Zongyou Guo (Author), Chi‐Kun Tong (Author), Joanna Jacków (Author), Yanne S. Doucet (Author), Hasan E. Abaci (Author), Wangyong Zeng (Author), Corey Hansen (Author), Ryota Hayashi (Author), Dominick DeLorenzo (Author), Avina Rami (Author), Alberto Pappalardo (Author), Ellen A. Lumpkin (Author), Angela M. Christiano (Author)
• Format: Book
• Published: Wiley, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Atopic dermatitis (AD), driven by interleukins (IL‐4/IL‐13), is a chronic inflammatory skin disease characterized by intensive pruritus. However, it is unclear how immune signaling and sensory response pathways cross talk with each other. We differentiated itch sensory neuron‐like cells (IS...