Crystal structure of ricin toxin A chain complexed with a highly potent pterin-based small-molecular inhibitor

• Main Authors: Masaru Goto (Author), Natsumi Sakamoto (Author), Shoko Higashi (Author), Rena Kawata (Author), Kazuki Nagatsu (Author), Ryota Saito (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ricin toxin A chain (RTA), from Ricinus communis, is a deadly protein that inactivates ribosomes by degrading an adenine residue at position 4324 in 28S rRNA. Recently, we have demonstrated that pterin-7-carboxamides with peptide pendants were potent RTA inhibitors. Among these, N-(pterin-7-carbonyl...