Quantitative Biodistribution and Pharmacokinetics Study of GMP-Grade Exosomes Labeled with ⁸⁹Zr Radioisotope in Mice and Rats

• Main Authors: Hojun Choi (Author), Myung-Yoon Kim (Author), Dae-Hwan Kim (Author), Hanoul Yun (Author), Byung-Koo Oh (Author), Su-Bin Kim (Author), In-Ho Song (Author), Hyun-Soo Park (Author), Sang-Eun Kim (Author), Cheolhyoung Park (Author), Chulhee Choi (Author)
• Format: Book
• Published: MDPI AG, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

For the successful clinical advancement of exosome therapeutics, the biodistribution and pharmacokinetic profile of exogenous exosomes in various animal models must be determined. Compared with fluorescence or bioluminescence imaging, radionuclide imaging confers multiple advantages for the in vivo...