Kaurane-Type Diterpenoids as Potential Inhibitors of Dihydrofolate Reductase-Thymidylate Synthase in New World <i>Leishmania</i> Species

• Main Authors: Chonny Herrera-Acevedo (Author), Renata Priscila Barros de Menezes (Author), Natália Ferreira de Sousa (Author), Luciana Scotti (Author), Marcus Tullius Scotti (Author), Ericsson Coy-Barrera (Author)
• Format: Book
• Published: MDPI AG, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The bifunctional enzyme Dihydrofolate reductase-thymidylate synthase (DHFR-TS) plays a crucial role in the survival of the <i>Leishmania</i> parasite, as folates are essential cofactors for purine and pyrimidine nucleotide biosynthesis. However, DHFR inhibitors are largely ineffective in...