Comparative permeability of three saikosaponins and corresponding saikogenins in Caco-2 model by a validated UHPLC-MS/MS method

• Main Authors: Siqi Ren (Author), Jingjing Liu (Author), Yunwen Xue (Author), Mei Zhang (Author), Qiwei Liu (Author), Jie Xu (Author), Zunjian Zhang (Author), Rui Song (Author)
• Format: Book
• Published: Elsevier, 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Saikosaponins (SSs) are the main active components extracted from Bupleuri Radix (BR) which has been used as an important herbal drug in Asian countries for thousands of years. It has been reported that the intestinal bacteria plays an important role in the in vivo disposal of oral SSs. Although the...