Conjugate-SELEX: A High-throughput Screening of Thioaptamer-liposomal Nanoparticle Conjugates for Targeted Intracellular Delivery of Anticancer Drugs

• Main Authors: Qingshan Mu (Author), Akshaya Annapragada (Author), Mayank Srivastava (Author), Xin Li (Author), Jean Wu (Author), Varatharasa Thiviyanathan (Author), Hongyu Wang (Author), Alexander Williams (Author), David Gorenstein (Author), Ananth Annapragada (Author), Nadarajah Vigneswaran (Author)
• Format: Book
• Published: Elsevier, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Patients with advanced head and neck squamous cell carcinoma receiving chemotherapy have a poor prognosis partly due to normal tissue toxicity; therefore, development of a tumor-targeted drug delivery platform to minimize collateral toxicity is a goal of cancer nanomedicine. Aptamers can achieve thi...