Lurbinectedin induces depletion of tumor-associated macrophages, an essential component of its in vivo synergism with gemcitabine, in pancreatic adenocarcinoma mouse models

• Main Authors: María Virtudes Céspedes (Author), María José Guillén (Author), Pedro Pablo López-Casas (Author), Francesca Sarno (Author), Alberto Gallardo (Author), Patricia Álamo (Author), Carmen Cuevas (Author), Manuel Hidalgo (Author), Carlos María Galmarini (Author), Paola Allavena (Author), Pablo Avilés (Author), Ramón Mangues (Author)
• Format: Book
• Published: The Company of Biologists, 2016-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We explored whether the combination of lurbinectedin (PM01183) with the antimetabolite gemcitabine could result in a synergistic antitumor effect in pancreatic ductal adenocarcinoma (PDA) mouse models. We also studied the contribution of lurbinectedin to this synergism. This drug presents a dual pha...