Pharmacological Blockade of IKs Destabilizes Spiral-Wave Reentry Under β-Adrenergic Stimulation in Favor of Its Early Termination

• Main Authors: Sara Kato (Author), Haruo Honjo (Author), Yoshio Takemoto (Author), Hiroki Takanari (Author), Tomoyuki Suzuki (Author), Yusuke Okuno (Author), Tobias Opthof (Author), Ichiro Sakuma (Author), Shin Inada (Author), Kazuo Nakazawa (Author), Takashi Ashihara (Author), Itsuo Kodama (Author), Kaichiro Kamiya (Author)
• Format: Book
• Published: Elsevier, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We tested a hypothesis that an enhancement of IKs may play a pivotal role in ventricular proarrhythmia under high sympathetic activity. A 2-dimensional ventricular muscle layer was prepared in rabbit hearts, and action potential signals were analyzed by optical mapping. During constant stimulation,...