Pioneer factor Foxa2 enables ligand-dependent activation of type II nuclear receptors FXR and LXRα

• Main Authors: Jessica Kain (Author), Xiaolong Wei (Author), Nihal A. Reddy (Author), Andrew J. Price (Author), Claire Woods (Author), Irina M. Bochkis (Author)
• Format: Book
• Published: Elsevier, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Type II nuclear hormone receptors, including farnesoid X receptors (FXR), liver X receptors (LXR), and peroxisome proliferator-activated receptors (PPAR), which serve as drug targets for metabolic diseases, are permanently positioned in the nucleus and thought to be bound to DNA regardles...