Pioneer factor Foxa2 enables ligand-dependent activation of type II nuclear receptors FXR and LXRα

• Päätekijät: Jessica Kain (Tekijä), Xiaolong Wei (Tekijä), Nihal A. Reddy (Tekijä), Andrew J. Price (Tekijä), Claire Woods (Tekijä), Irina M. Bochkis (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Elsevier, 2021-11-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Objective: Type II nuclear hormone receptors, including farnesoid X receptors (FXR), liver X receptors (LXR), and peroxisome proliferator-activated receptors (PPAR), which serve as drug targets for metabolic diseases, are permanently positioned in the nucleus and thought to be bound to DNA regardles...