Pioneer factor Foxa2 enables ligand-dependent activation of type II nuclear receptors FXR and LXRα

• मुख्य लेखकों: Jessica Kain (लेखक), Xiaolong Wei (लेखक), Nihal A. Reddy (लेखक), Andrew J. Price (लेखक), Claire Woods (लेखक), Irina M. Bochkis (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2021-11-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Objective: Type II nuclear hormone receptors, including farnesoid X receptors (FXR), liver X receptors (LXR), and peroxisome proliferator-activated receptors (PPAR), which serve as drug targets for metabolic diseases, are permanently positioned in the nucleus and thought to be bound to DNA regardles...