KDM6A Lysine Demethylase Directs Epigenetic Polarity of MDSCs during Murine Sepsis

• Päätekijät: Isatou Bah (Tekijä), Tuqa Alkhateeb (Tekijä), Dima Youssef (Tekijä), Zhi Q. Yao (Tekijä), Charles E. McCall (Tekijä), Mohamed El Gazzar (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Karger Publishers, 2021-07-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Sepsis-induced myeloid-derived suppressor cells (MDSCs) increase mortality risk. We previously identified that long non-coding RNA Hotairm1 supports myeloid precursor shifts to Gr1+CD11b+ MDSCs during mouse sepsis. A major unanswered question is what molecular processes control Hotairm1 expression....